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After graduating from high school, Joe moved to Hollywood, where he began his film career. His talent was noticed early, and he quickly became one of the most sought-after actors in the industry.

Joe took his first steps in films in the 1970s, such as Racing Horse (1979) and Racing Drive (1980). However, he became famous for his roles in such cult films as Once Upon a Time in America (1984), Dark Affairs (1990) and The Matrix (1999).

He also starred in many television series, including "The Sopranos," where his role as Ralphie Cifaretto was particularly memorable.

Joe Pantogliano continues to delight viewers with his talent and professionalism. His multifaceted and exciting performances make him one of the most respected and recognized actors in the film and television industry.