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His acting debut took place in the early 1980s, when he starred in small roles in television series. However, his real breakthrough was the film "Lost Guys" (1983), where he played one of the main roles. This film brought him wide acclaim from critics and viewers, and established his status as a talented actor.

Rob Lowe has since appeared in a variety of successful films including:

1. Peaky Blinders (1985) is a dramatic film about the lives of young Americans.

2. Wolf Summer (1987) is an adventure comedy about the adventures of teenagers.

3. The Secret Window (2004) is a thriller based on the novel by Stephen King.

However, Rob Lowe has also been active in television series, including successful projects such as Sons of Anarchy and Parks and Recreation. His talent and professionalism made him one of Hollywood's most valuable actors.

Rob Lowe continues to amaze viewers with his diverse roles and deep acting skills. His career continues to evolve and his work continues to inspire and entertain audiences around the world.