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After leaving school, she entered the London Academy of Music and Dramatic Art (LAMDA), where she received a professional acting education and developed her creative abilities.

Her acting debut took place in the late 1970s, when she began acting in theatrical productions and television series. She quickly caught the attention of critics and viewers with her talent and emotional depth of play.

Some of Louise Fletcher's more notable works include:

- "One Flew Over the Cuckoo's Nest" (1975): In this drama, she played the role of a matron in a psychiatric hospital, for which she was awarded the Academy Award for best actress.

- "The House That Jack Built" (2018): In this thriller, she played a major role, demonstrating her acting talent and professionalism.

- "Fire with Fire" (2020): In this dramatic film, she played the role of an older lady facing family secrets and tragic events.

Louise Fletcher continues to actively act in films and television, winning the hearts of the audience with her unique performances. Her talent and professionalism make her one of the most outstanding actresses of her generation, and her work will remain in the memory of the audience for a long time.